Keeping Company with Seabright

Is very high sympathetic tone in heart failure a result of keeping bad company?

The sympathetic nervous system is activated in patients with heart failure, with increase in the sympathetic outflows to the heart, kidneys, and the skeletal muscle vasculature having been clearly demonstrated through the use of isotope dilution-derived measures of norepinephrine spillover and the sympathetic nerve recording technique of clinical microneurography.1–3 Prognosis in cardiac failur...

Keeping up with Change

Keeping up with calcium

Our understanding of how calcium functions as a second messenger continues to increase at an incredible pace. This symposium covered most, if not all, aspects of the many roles of calcium in the regulation of cellular processes and ranged from calcium imaging through to the structure and function of calcium-binding proteins. Emphasis was placed on elucidating the involvement of these proteins i...

Keeping Secrets with Public Communication

Given some deal of cards, it is possible to communicate your hand to another player without yet another player learning any of your cards. Every solution to this problem consists of a sequence of safe communications, an interesting new form of update. Certain unsafe communications turn out to be unsuccessful updates. Each communication can be about a set of alternative card deals only, and even...

Keeping Pace with Extreme Data

A fter perusing the articles and guest editors’ introduction for this issue on extreme data, I googled “extreme,” and hundreds of links bubbled up—from computing, coupons, data, and fatigue, to science, scientists and science fun, to “extreme x” (don’t ask). I then concluded that “extreme” has become an unreliable buzzword, used somewhat indiscriminately for its shock value. That said, the fact...